In This Article


Glucosamine is one of the most widely used supplements all over the world. It aids in the formation of cartilage, the tissue that cushions joints. If you utilize glucosamine, you can lessen the impact on your joints, such as your knees and hips.

Glucosamine: Benefits, Negative Side Effects & Recommended Dosages
Which Glucosamine Is Best?

People who do a lot of high-impact workouts are more likely to develop osteoarthritis. As you get older, this usually gets worse. You can reduce the intensity of the problem by taking glucosamine.

Some glucosamine products are incorrectly labeled. The amount of glucosamine actually in the product may range from none to more than 100% of the amount specified on the label in some situations. When glucosamine sulfate is indicated on the label, some of such products tend to include glucosamine hydrochloride. For osteoarthritis, the most frequent supplements are glucosamine sulfate and glucosamine hydrochloride.

Sources of Glucosamine

Although glucosamine sulfate supplements are mostly made from fish shells, there are no natural glucosamine dietary sources. Glucosamine is a substance that your body can make on its own. Animal cartilage is one of the most convenient sources of glucosamine.

Dog meat contains a lot of glucosamine, however most people don't consume it. Crustacean shells such as lobster, prawns, and crabs are also good sources. Wheat and corn are also excellent sources of glucosamine in plants.

Glucosamine Benefits


Osteoarthritis is a disorder characterized by joint degeneration. The majority of evidence suggests that taking glucosamine sulfate can help persons with osteoarthritis, particularly those with osteoarthritis of the knees, feel better. Glucosamine sulfate may be as effective as over-the-counter and prescription pain relievers like acetaminophen or ibuprofen for some people.

Joint discomfort

A class of medications known as aromatase inhibitors can be responsible for this (aromatase inhibitor-induced arthralgia). According to preliminary studies, taking a daily dose of glucosamine sulfate and chondroitin sulfate in two or three divided doses for 24 weeks decreases pain in women using estrogen-lowering medications for early-stage breast cancer.

Cystitis interstitial

Interstitial cystitis (IC) is a disorder caused by a lack of the chemical glycosaminoglycan. Glucosamine is commonly marketed as a treatment for IC. Because glucosamine is a precursor to this chemical, it's thought that taking glucosamine supplements could help with IC management.[1]


Glucosamine is widely believed to be useful in treating glaucoma. According to preliminary research, glucosamine sulfate can help with eye health by lowering inflammation and delivering antioxidant effects in the retina.[2]

Irritable Bowel Syndrome (IBS)

Irritable Bowel Syndrome (IBS) is a condition in which the intestines (IBD) Interstitial cystitis, like inflammatory bowel disease (IBD), is associated to a glycosaminoglycan deficiency.

There is only a little amount of evidence that glucosamine can help in IBD. According to a study, glucosamine supplementation may reduce inflammation in animals with IBD.

Glucosamine Negative Side Effects

Glucosamine is regarded safe and has been approved for the treatment of osteoarthritis in many European nations. The glucosamine impact is more apparent than placebos, according to a safety study. It is significantly safer to use than most NSAIDs, which can cause serious side effects or even death. Diabetics can also utilize glucosamine because it has no influence on blood sugar levels. For the most part, glucosamine supplements are considered to be safe. However, there are potential dangers.
Among the possible side effects are:

  • Vomiting and nausea
  • Diarrhea
  • Heartburn
  • Pain in the abdomen

Due to a lack of data supporting its safety, you should avoid taking glucosamine if you're pregnant or breastfeeding. For persons with diabetes, glucosamine may affect blood sugar control, albeit this is a small risk. Before using glucosamine, consult your doctor if you have diabetes or are taking diabetes drugs.[3]

Although glucosamine side effects appear to be minor and infrequent, they can include:

  • indigestion
  • constipation
  • diarrhea
  • headaches
  • rashes

Doses of Glucosamine to Take and When to Take It

The daily recommended dose of glucosamine is 1500 mg. It's available in three different dosages: 500 mg three times a day or as a single concentrated tablet once a day.

Take it with your meals if you have a sensitive stomach. You will begin to notice the results after a few months.
Glucosamine supplements can be derived from natural sources like shellfish shells or fungi, or they can be synthesized in a lab.

There are two types of glucosamine supplements:

  • Glucosamine sulfate
  • Glucosamine hydrochloride

Glucosamine sulfate is sometimes offered alongside chondroitin sulfate.

The majority of scientific evidence suggests that glucosamine sulfate mixed with chondroitin has the highest efficacy.

Supplements Containing Glucosamine

It's available in powder or tablet form as a standalone supplement. Glucosamine is one of the most used components in joint supplements. Glucosamine sulfate and glucosamine hydrochloride are two common types of glucosamine (HCL).

Glucosamine sulfate is less absorbable than HCL.

Glucosamine sulfate supplements are used for a variety of reasons, including:

  • Osteoarthritis
  • Glaucoma
  • Loss of weight
  • a sore jaw
  • achy joints
  • back ache
  • interstitial cystitis, which is a bladder disease.
  • Multiple sclerosis (MS) (MS)
  • Cardiovascular disease

However, there is little data to suggest that it is effective in the treatment or prevention of any of these diseases.

You May Also Like to Read: Health Benefits of Horsetail

Frequently Asked Questions

Q: What is the function of glucosamine?

A: People take glucosamine sulfate orally to relieve discomfort caused by cartilage inflammation, degradation, and eventual loss (osteoarthritis).[4]

Q: Is glucosamine effective?

A: For those with osteoarthritis, glucosamine sulfate may provide some pain relief. The supplement appears to be safe, and it could be a good alternative for people who are unable to use no steroidal anti-inflammatory medicines (NSAIDs). While the findings of the studies are varied, glucosamine sulfate may be worth a shot.

Q: How long does glucosamine take to become effective?

A: Glucosamine does not have an immediate effect. It's possible that you'll need to take the supplements for four to six weeks before you see any results. If your symptoms haven't improved by then, the supplements are unlikely to help you, and you should consult your doctor about other options for controlling your arthritis.

Q: Is glucosamine good for arthritis?

A: People with osteoarthritis of the knee can benefit from taking glucosamine sulfate orally. According to certain studies, it may also aid in the slowing of osteoarthritis-related knee joint deterioration.

Q: How can you acquire glucosamine in a natural way?

A: The natural chemical glucosamine is present in cartilage, the strong tissue that cushions joints.

Was this article helpful?

4 Sources

We review published medical research in respected scientific journals to arrive at our conclusions about a product or health topic. This ensures the highest standard of scientific accuracy.