In This Review

What Are Depression Supplements?

Depression is a common mood disorder that affects millions of people around the world. Technically, depression is a term that refers to a group of mood disorders that are similar, sometimes related, but clinically distinct.

Depression supplements are natural or herbal remedies marketed as treatment methods. These supplements generally contain a blend of minerals, herbs, and vitamins that can, in some cases, improve mood, relieve stress, and decrease the symptoms of depression.

“Depression is a common mental health condition with varying degrees of severity that can be treated using a variety of approaches.” says Emily Steinberg, MD

St. John’s wort, omega-3 fatty acids, SAM-e, and 5-HTP are all common ingredients in anti-anxiety supplements. While some studies have suggested that these substances help with depression symptoms, the evidence is often conflicting, and more research is needed to fully understand their effectiveness.

How We Researched The Best Depression Supplements?

Dr. Robert S. Rosenberg DO, FCCP is the medical director of the Sleep Disorders Center of Prescott Valley in Arizona, and a sleep medicine consultant for Mountain Heart Health Services in Flagstaff. Before selecting dozens to test, he researched the most popular and highly rated depression supplements on the market, taking expert recommendations and consumer reviews into account. Kelly Faltersack, MS, RDN, is a registered dietitian nutritionist at UW Health in Madison, Wisconsin. Kelly is a registered dietitian nutritionist with over ten years of experience. They researched and studied each product, taking into account online reviews and evaluating the best depression supplement based on customer satisfaction.

colanAccording to Exclusive Best Offer Research & Approved, Our best overall pick is Vitapost Stress Support a dietary supplement that provides the body with a healthy stress response and relaxed breathing. For a more affordable pick, NuviaLab Relax is a dietary supplement designed to alleviate symptoms of depression and anxiety.colan-1

Our Top Picks


Best Supplements For Depression in 2024

If you're looking for the best supplement for depression that will work for you, here is a rundown of the nine best depression supplements for 2024.

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Vitapost Stress Support | Best Supplement For Mood

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Vitapost Stress Support

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(4.9/5) 134 REVIEWS
PRODUCT HIGHLIGHTS
  • High-Quality Ingredients
  • Non GMO
  • Gluten Free
  • Vegan Friendly
  • Made In The USA
  • Form: Capsule
  • Brand: Vitapost
  • Quantity: 60 Capsules
  • Dosage: 2 Capsules Per Day
  • Ingredients: Chamomile, L-theanine Green Tea, Hops, Lemon Balm, Valerian
  • Usage: Supports a Healthy Stress Response, Supports Calm & Relaxation, Supports Positive Mood
  • Safety: Non-GMO, Gluten Free, FDA Registered Facility
  • Refund Policy: 30-Day
  • Company Info: Vita Balance Inc, 7400 Beaufont Springs Drive, Suite 300, Richmond, Virginia 23225, United States, support@vitabalance.net, +1 888-455-9995
reviews

Best pills for depression and anxiety!!

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“I can't express enough how grateful I am to have found these best pills for depression and anxiety. I occasionally experience mild depression, and I frequently experience anxiety during work presentations or other stressful situations. I started taking it and it really helps to balance my mood, boost my positivity, and reduce my anxiety. I'm so glad I found it!” - Maira

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VitaPost Stress Support is a dietary supplement that claims to help manage stress and anxiety. According to the provided search results, the supplement contains several ingredients believed to have calming properties, including ashwagandha, lemon balm, and passionflower. The supplement also contains vitamins and minerals, including B vitamins and magnesium, which are thought to support the nervous system and promote overall well-being.

The stress support pill gives the body a healthy stress response and relaxed breathing, leading to better moods. It also improves users’ sleeping hours while helping them sleep soundly through the night.

colanAccording to Journal of Clinical Psychopharmacology[1], “Chamomile tea improved postpartum women's sleep quality, fatigue, and depressive symptoms, and it contains compounds that can help boost immune function and protect against infections.”colan-1

It is important to note that supplements should not be used as a substitute for professional medical advice or treatment. Individuals with stress or anxiety should consult with a healthcare professional to determine the most appropriate course of treatment for their individual needs. Results may vary among individuals. .

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Restilen | Best Natural Remedy For Depression

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Restilen

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(4.8/5) 256 REVIEWS
PRODUCT HIGHLIGHTS
  • Natural Ingredients
  • Vegan Friendly
  • Gluten Free
  • Made In The EU
  • Affordable Price
  • Form: Capsule
  • Brand: Restilen
  • Quantity: 60 Capsules
  • Dosage: 1 Capsules Per Day
  • Ingredients: Ashwagandha Root Extract, KSM -66, Sweet Orange Peel Extract, Green Tea Leaf Extract
  • Usage: Reduces Fatigue and Exhaustion, Reduces Stress Symptoms
  • Safety: Vegan Friendly, Gluten Free
  • Refund Policy: NA
  • Company Info: NA
reviews

Best vitamins for depression!!

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“It really helped me with mood balance, but I took it every day for five, going on six months. It was great for the first few months then maybe my tolerance grew or something because it sort of crapped out on me. Works in the short term, though!” - Sally Garcia

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Restilen is advertised as a natural supplement for depression that helps manage stress and anxiety. It does this through clinically proven ingredients that have been shown to reduce fatigue, improve mood, decrease stress, and help the nervous system work better. It contains a blend of vitamins, minerals, and herbal extracts.

Some of the key ingredients in Restilen include ashwagandha, passionflower, lemon balm, magnesium, and B vitamins. Ashwagandha is an adaptogenic herb that is believed to help the body cope with stress, while lemon balm and passionflower are believed to have calming effects on the nervous system. Magnesium and B vitamins are essential for proper nerve function and a healthy mood.

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NuviaLab Relax | Best For Brain Function

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NuviaLab Relax

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(4.9/5) 167 REVIEWS
PRODUCT HIGHLIGHTS
  • Natural Ingredients
  • Vegan Friendly
  • Gluten Free
  • Made In The EU
  • 100% Money Back Guarantee
  • Form: Capsule
  • Brand: NuviaLab Relax
  • Quantity: 60 Capsules
  • Dosage: 2 Capsules Per Day
  • Ingredients: Calmomix, Rhodiolife, Vitamin, Mineral Complex
  • Usage: Supports Brain Function and Cognitive Abilities
  • Safety: Non GMO, Dairy Free, Vegan Friendly, Gluten Free
  • Refund Policy: 14-Day
  • Company Info: NuviaLab Limited, 50 Stanley Street, World Trust Tower, Hong Kong
reviews

Best depression anxiety medication!!

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“I’ve been taking NuviaLab Relax for the last few months, and I’ve already noticed a change in my body and it helps you relax and remain calm in stressful situations. It is a bit gritty and does not dissolve that well. Overall, I am thoroughly impressed with this product.” - Conor V.

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NuviaLab Relax is a dietary supplement designed to alleviate symptoms of depression and anxiety. It contains a one-of-a-kind complex of ingredients that can help you relax and remain calm in stressful situations. The product’s composition comprehensively supports the nervous system, brain function, and cognitive abilities. This allows you to perform daily tasks more effectively without the adverse effects of stress on concentration and performance. Furthermore, it improves sleep quality and makes it easier to fall asleep, promoting restful sleep throughout the night.

colanAccording to Journal of Ethnopharmacology[2], “Rhodiolife was more effective than a placebo in improving depressive symptoms, implying that it could be a useful supplement for depression. It, like antidepressants, may have a positive effect on neurotransmitters that affect mood and emotion.”colan-1

As with any supplement, it is essential to consult a healthcare professional before use, especially if you have any underlying medical conditions or are taking medication.

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Pure Encapsulations Rhodiola Rosea | Best Supplement For Depression

pure encapsulations rhodiola rosea

Pure Encapsulations Rhodiola Rosea

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(3.3/5) 110 REVIEWS
$21.20AMAZON
$37.85WALMART
PRODUCT SPECIFICATIONS
  • Form: Capsules
  • Brand: Pure Encapsulations
  • Quantity: 180 Capsules
  • Dosage: 1 Capsules Per Day
  • Ingredients: Rhodiola Extract, Hypoallergenic Plant Fiber
  • Usage: Supports Healthy Glucose Metabolism, Promote Endurance
  • Safety: High Quality Ingredients, Gluten Free, GMO Free
  • Refund Policy: 30-Day
  • Company Info: Pure Encapsulations, LLC, 490 Boston Post Road, Sudbury, MA 01776, customerservice@pureencapsulations.com, +1 (800) 753-2277
reviews

Great equalizer.

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“Rhodiola Rosea by Pure Encapsulations is a great herb. So, I don't take it all the time, just on occasions when I need to balance my hormones. This product works for me!! I like the size of the Pure Encapsulations capsules very easy to swallow.” - Darrell B.

Pure Encapsulations Rhodiola Rosea is a supplement that is thought to help with depression symptoms. Rhodiola Rosea is a traditional medicine used for centuries to treat fatigue, stress, and anxiety. Rhodiola Rosea reduces mental and physical stress and promotes endurance. It also supports proper carbohydrate metabolism and cell function.

Emily Steinberg, MD says, “Hypoallergenic Plants Fibre has beneficial effects on gut health and inflammation, which are thought to be related to mood and mental health.”

It is made with high-quality, natural ingredients that are free of artificial preservatives, colours, and flavours. It's also gluten-free, non-GMO, vegan, and vegetarian-friendly.

Official Website

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Nordic Naturals EPA Xtra | Best Supplement For Anxiety and Depression

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Nordic Naturals EPA Xtra

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(3.2/5) 20 REVIEWS
$41.95AMAZON
$35.66WALMART
PRODUCT SPECIFICATIONS
  • Form: Softgels
  • Brand: Nordic Naturals
  • Quantity: 60 Softgels
  • Dosage: 2 Softgels Daily
  • Ingredients: Omega-3, Rosemary Extract, Glycerin, D-alpha Tocopherol
  • Usage: Support for Cardiovascular Health, Mood Health
  • Safety: Gluten Free, Dye Free, GMO Free
  • Refund Policy: 60-Day
  • Company Info: 111 Jennings Drive, Watsonville, CA 95076, international@nordicnaturals.com, +1 800-662-2544
reviews

Best supplements for mood enhancement.

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“I started taking EPA to help with chronic dry eye and it appears to be helping. I started with a higher price product but found Nordic Naturals with Lemon at GNC at a much better price for a quality suppliment.” - Maira

Nordic Naturals EPA Xtra is a dietary supplement containing a high concentration of the omega-3 fatty acid eicosapentaenoic acid (EPA), which is thought to have anti-inflammatory and mood-regulating properties. The supplement is marketed as a natural means of boosting emotional well-being and mental outlook. Omega-3 fatty acids are important nutrients for brain health and have been shown to reduce inflammation and improve symptoms of depression and anxiety. Nordic Naturals EPA Xtra contains a high concentration of EPA, which is thought to be more effective than EPA and docosahexaenoic acid supplements (DHA).

colanAccording to Research[3], “Omega-3 supplements may have antidepressant properties. It may help to regulate mood and reduce brain inflammation, which may be linked to depression. Furthermore, omega-3 supplements may provide additional health benefits, such as lowering the risk of heart disease and improving cognitive function.”colan-1

Nordic Naturals EPA Xtra contains 1060 mg of EPA and 274 mg of DHA (docosahexaenoic acid), another important omega-3 fatty acid, and is made from 100% wild-caught, sustainably sourced Arctic cod. The supplement is gluten-, dairy-, and artificial ingredient-free and is available in liquid and softgel form.

Official Website

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Thorne Creatine | Best Antidepressant For Energy and Motivation

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Thorne Creatine

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(3.5/5) 520 REVIEWS
$39.99AMAZON
$29.98WALMART
PRODUCT SPECIFICATIONS
  • Form: Powder
  • Brand: Thorne Research
  • Quantity: 450gm
  • Dosage: 1 Scoop Daily
  • Ingredients: Creatine, Amino Acids, Magnesium, Nutritional Supplement
  • Usage: Enhances Strength and Promotes Lean Body Mass
  • Safety: Gluten Free, Keto - NSF Certified for Sport
  • Refund Policy: 60-Day
  • Company Info: USA, support@thorne.com, +1 (800) 228-1966
reviews

Best supplement for mental health.

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“I just started working out 4-5 times a week and this creatine has really helped with my workouts. I feel confident that I am using a clean product that helps my body recover and get better after a long day at the gym. I highly recommend it.” - Hsinyi L.

Thorne Creatine is a dietary supplement containing creatine monohydrate, a naturally occurring compound in the body involved in muscle cells’ energy production.. Creatine has been researched for its potential benefits in improving athletic performance and muscle strength, but some research suggests it may also have mental health benefits.

Creatine can also be found in meat, eggs, and fish. It aids in the production of cellular energy by assisting in the formation of ATP, a molecule required for intense exercise, as well as providing energy to pump your heart and power your brain.

colanAccording to Study[4], “Tryptophan is an amino acid that is usually converted to different significant molecules such as serotonin and melatonin. Tryptophan and the molecules it produces have such an impact on many bodily functions, including sleep, mood, and behaviour.”colan-1

Thorne Creatine is suitable for collegiate and professional athletes because it is NSF-certified and does not contain any banned substances.

Official Website

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Thorne Vitamin D/K2 Liquid | Best Vitamin For Anxiety and Depression

thorne-vitamin-dk2 liquid

Thorne Vitamin D/K2 Liquid

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(3.6/5) 124 REVIEWS
$28.00AMAZON
$28.00WALMART
PRODUCT SPECIFICATIONS
  • Form: Liquid
  • Brand: Thorne Research
  • Quantity: 30ml
  • Dosage: 2 Drops One to Three Times Daily
  • Ingredients: Vitamin D3, Vitamin K2, Medium Chain Triglycerides
  • Usage: Bone & Joint Support, Heart Support, Immune Support
  • Safety: Gluten Free, Soy Free
  • Refund Policy: 60-Day
  • Company Info: USA, support@thorne.com, +1 (800) 228-1966
reviews

Best vitamins for depression and anxiety!!

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“For the past few years, I have just put the drops in my glass of water. Finally, after all this time, I just opened my mouth and dripped it on my tongue. Voila...done. No taste, no leftover residue. My D has increased over the last two years, and I have not really done anything else differently. I highly recommend this simple way of taking it!” - Gillian B.

Thorne Vitamin D/K2 Liquid is an antioxidant-rich dietary supplement that combines Vitamin D3 (cholecalciferol) and Vitamin K2 (menatetrenone) with medium-chain triglycerides. Thorne Research is a well-known manufacturer of high-quality supplements, and their Vitamin D/K2 Liquid is no exception. The combination of vitamins D3 and K2 is specifically designed to support bone health, immune function, calcium metabolism, and cardiovascular health.

colanAccording to Research[5], “Vitamin K2 improved blood glucose control and reduced anxiety and depression. Vitamin K2 may have an indirect effect on mood by enhancing cardiovascular health and decreasing inflammation.”colan-1

The liquid format includes a metered dispenser for precise dosing, with a recommended dosage of 2 drops per day. Because vitamin D and K2 are essential nutrients that are not always obtained in sufficient quantities through diet, supplementation is a convenient and effective way to support overall health.

Official Website

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Pure Encapsulations NAC | Best Over the Counter Antidepressant

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Pure Encapsulations NAC 900 mg

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(3.4/5) 660 REVIEWS
$74.87AMAZON
$47.40WALMART
PRODUCT SPECIFICATIONS
  • Form: Capsules
  • Brand: Pure Encapsulations
  • Quantity: 120 Capsules
  • Dosage: 2 Capsules Per Day
  • Ingredients: N-Acetyl-l-Cysteine
  • Usage: Promotes Healthy Lung Tissue and Respiratory Function
  • Safety: Gluten Free, GMO Free, Vegan
  • Refund Policy: 30-Day
  • Company Info: Pure Encapsulations, LLC, 490 Boston Post Road, Sudbury, MA 01776, customerservice@pureencapsulations.com, +1 (800) 753-2277
reviews

Best treatment for depression and anxiety!!

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“Works well but I had to cut back on taking it everyday because it dries out my fingers. I normally have cracks around my fingers but with this it really dries out and some of cracks will bleed. Now I only take them on weekends before I have some cocktails. I'm thinking it my be a healing detox that is causing this issue.” - Celina

Pure Encapsulations NAC 900 mg is a dietary supplement that contains N-Acetyl Cysteine (NAC), an amino acid that has been shown to provide cellular antioxidant support to the body. This supplement supports overall lung and immune system health, as well as liver function and antioxidant activity.

NAC has been the subject of several studies, including a recent meta-analysis of eight double-blind, placebo-controlled trials that demonstrated its effectiveness in supporting respiratory health. Pure Encapsulations is a higher-end supplement brand known for its purity and potency.

Official Website

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Nature's Trove SAM-e | Best SAM-e Supplement

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Nature's Trove SAM-e

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(3.5/5) 32 REVIEWS
$39.85AMAZON
$31.65WALMART
PRODUCT SPECIFICATIONS
  • Form: Caplets
  • Brand: Nature's Trove
  • Quantity: 90 Caplets
  • Dosage: 2 Caplets Per Day
  • Ingredients: Silicon Dioxide, Sodium Starch Glycolate, S-adenosyl-L-methionine, Yellow Ochre
  • Usage: Brain Health Support, Support Positive Mood
  • Safety: Vegan, GMO Free, Kosher Certified
  • Refund Policy: NA
  • Company Info: 2360 Lakewood Road Suite 3 #184, Toms River, NJ 08755, info@naturestrove.com, +1 800 850 6510
reviews

Best depression pills!!

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“Nature’s Trove SAM-e does exactly what they say. It has a great calming effect and minimizes stress. In my work, I travel city streets a great deal. There are a lot of damn fools on the roads, and I find myself getting angry too often. Thankfully, I didn't do anything stupid. I don't worry so much about that anymore. People do dumb stuff, and I just shake my head a little and continue on. Great product! It worked wonders for me! This product has worked wonders for me, and I can confidently say it's the best natural supplement for depression that I've come across. If you're looking for a reliable solution to maintain your composure and navigate life's challenges with ease, this is it!” - Donna P.

Nature’s Trove SAM-e is a dietary supplement that contains S-adenosylmethionine (SAM-e). This naturally occurring compound is involved in various biochemical processes in the body, including the synthesis of neurotransmitters and the regulation of mood, joint health, and liver function.

SAM-e is a methyl donor, which means it provides a methyl group to other molecules in the body. This process is essential for producing of neurotransmitters such as serotonin, dopamine, and norepinephrine, which play a vital role in regulating mood and emotions.

colanAccording to Study[6], “S-adenosyl-L-methionine (SAM-e) is a naturally occurring compound that plays a role in a variety of biochemical processes in the body, including mood regulation and neurotransmitter function. SAMe is also involved in the synthesis of several compounds in the body, including neurotransmitters and phospholipids, both of which are important in mood regulation.”colan-1

The SAM-e supplement is made from high-quality SAM-e that is manufactured using a unique, stabilised form of the compound, which ensures maximum potency and bioavailability. The supplement is designed to be easy to swallow and is available in a range of strengths to suit individual needs.
Official Website

How To Choose The Best Supplements For Depression?

do supplements really work for depression

When you are looking for effective relief from everyday depression, you should consider natural supplements for depression that take a complete approach to both symptom resolution and improving the quality of your life.

The product should restore and balance healthy neurological function and provide the nutritional support your body needs for overall well-being. You might not need to resort to prescription-strength drugs to achieve your depression and anxiety relief goals. However, you and your doctor should discuss supplements as part of your treatment plan.

Research The Supplement

Look for reliable information sources, such as scientific studies or reviews from trusted healthcare professionals. Beware of supplements that make lofty claims or promises without supplying sufficient proof to back them up.

Examine the Ingredients

When choosing ingredients for depression supplements, it is critical to focus on those shown in research studies to be effective. Read supplement labels carefully, especially if you have special dietary needs or choices, such as food allergies. Some people may also prefer to avoid supplements with additives like artificial colours and preservatives.

Choose Quality Supplements

Look for supplements made by reputable companies that follow sound manufacturing practises. Purity and potency of quality supplements should also be tested.

Look at Form and Dosage

Some supplement forms, such as softgels, are easier to swallow. If you have trouble remembering to take supplements or if you are taking other vitamins or medications, you may want to consider a product that you only need to take once a day.

Consider Price

Supplements can be costly, so it's important to compare prices, especially if you're on a low budget.

Can You Battle Depression Naturally?

can you battle depression naturally

Nearly 15 million Americans suffer from depression each year due to a chemical imbalance in the brain, but many symptoms are not severe enough to take medication long-term. Many people suffer from a serotonin deficiency causing mild symptoms of depression and anxiety.

Most symptoms of depression are short-term due to a loss of a loved one, seasonal disorders, life changes such as going to school, having a baby, losing a job, postpartum depression, and many others.

In an increasingly health-conscious society, it comes as no surprise that individuals grappling with mild to moderate depression are actively seeking depression supplements for relaxation as a means to manage their symptoms.

Many people who have used prescription antidepressants have discontinued their use due to the side effects being worse than the actual depression itself. Side effects of the more common antidepressants (Zoloft, Paxil, Effexor, Lexapro and more), have included suicidal tendencies, sexual dysfunction, dry mouth, urinary retention, constipation, blurred vision, headache, weight gain, gastrointestinal disturbance and more.

“Depression is a multifaceted disorder involving biological, psychological, and social factors. It is not a flaw or a personal failing, and it cannot be resolved simply by willpower. Seeking the assistance of a mental health professional is an important first step in dealing with depression.” explain Dr. Michael Craig Miller

The best supplements for depression have been proven a safer alternative by working to encourage the production of serotonin and other neurological chemicals such as norepinephrine in the human brain, promoting a sense of calm, well-being, and revitalization. Under a doctor’s supervision, taking supplements is an approach that has many seeing better results without negative side effects.

Are Antidepressant Supplements Effective?

Depression supplements' effectiveness varies depending on the individual, the supplement used, and the severity of the depression. While some people may find that supplements can help them manage their depression symptoms, they should not be used as a substitute for medical treatment.

Supplements should only be used in conjunction with other forms of treatment, such as psychotherapy or medication, if recommended by a physician. Supplements should also be taken under the supervision of a healthcare provider because some supplements can interact with prescription medications or cause side effects.

It's also worth noting that not all supplements marketed for depression have been thoroughly researched in clinical trials, and their efficacy may be questionable.

What You Must Know About Ingredient In Depression Supplements

There are several ingredients that are commonly found in supplements marketed for depression. Some of these ingredients include:

Omega-3 Fatty Acids

Omega-3 fatty acids are a common ingredient in depression supplements, and there is some evidence that they may help people with depression improve their mood. Omega-3 fatty acids are essential fatty acids found in fish, fish oil, and certain plants.

Vitamin D

Vitamin D is a common ingredient in depression supplements because research indicates that it may help alleviate depressive symptoms. Individuals with depression are more likely to have low vitamin D levels, so supplementing with vitamin D may be beneficial[7].

St. John's Wort

St. John’s Wort is a herb that has been used for centuries to treat a variety of ailments, including depression. Some evidence suggests that it may have antidepressant properties, but its effectiveness and safety as a supplement for depression are still debated[8].

SAM-e(S-adenosyl-L-methionine)

SAM-e, a molecule that is formed naturally in the human body, has shown antidepressant effects and may expand the available options for treating major depressive disorder (MDD). This systematic review examines the evidence concerning the efficacy of SAM-e as monotherapy or in combination with antidepressants.

It's important to note that while these ingredients may be helpful for some people with depression, they are not a substitute for professional treatment. If you are suffering from depression, it is essential that you seek treatment from your doctor or a mental health professional.

Product Comparison

Here's a short comparison of our top recommendations to make your decision easier:

Vitapost Stress Support Restilen NuviaLab Relax Thorne Creatine Nature’s Trove SAM-e
Rating star-4.9 star-4.8 star-4.9 star-3.5-1 star-3.5-1
Cost $29.95 $59.00 $49.00 $39.99 $39.85
Dosage 2 Capsules Per Day 1 Capsules Per Day 2 Capsules Per Day 1 Scoop Daily 2 Caplets Per Day
Usage Supports a Healthy Stress Response Reduces Fatigue and Exhaustion Supports Brain Function and Cognitive Abilities Enhances Strength and Promotes Lean Body Mass Brain Health Support
Return Policy 30-Day NA 14-Day 60-Day NA
Pros Non-GMO, Gluten Free Vegan Friendly, Gluten Free Non GMO, Dairy Free Keto – NSF Certified for Sport GMO Free, Kosher Certified
Review Most Affordable Deal Highly Recommended Good Results Results into Side Effects Expensive & Less Effective
Shop Now

Frequently Asked Questions

Q: Which supplements are commonly used for depression?

A: Certain dietary supplements, such as omega-3s, vitamin D, rhodiola, B12, and saffron, have been shown in studies to help some people reduce depressive symptoms.

These supplements, however, may not be appropriate or effective for everyone.

Before beginning any new dietary supplement, consult with a healthcare professional. This is especially critical if you take antidepressants or other medications.

Q: What is the most effective natural antidepressant supplement?

A: There is no one “best” natural antidepressant supplement, as different supplements may work better for different people depending on their unique needs and circumstances. Although some supplements have been shown to benefit certain populations with depression, not all supplements will benefit everyone.

Every person with depression has unique needs, so they should collaborate with a healthcare professional to generate an individualized treatment plan that may or may not involve dietary supplements.

Q: What is the most effective herb for anxiety and depression?

A: While certain supplement herbs, such as rhodiola and chamomile, may help some people reduce or eliminate their symptoms, there is no best herb for treating anxiety or depression.

Furthermore, while taking a herbal supplement may be beneficial, it should not be used in place of antidepressant medication prescribed by a doctor.

Final Words

Depression is a mental health condition that affects millions of people around the world. Although medication and therapy are typically used to treat depression, some people may wish to try other safe methods, such as dietary changes or supplements, to alleviate their symptoms.

Depression can result in significant pain and impairment, as well as an increased risk of suicide. However, effective treatments such as therapy, medication, and lifestyle changes are available.

It is critical to collaborate with a healthcare professional to develop an appropriate treatment plan. Many people suffering from depression can manage their symptoms and improve their quality of life with the right treatment and support. If you or someone you know is experiencing symptoms of depression, seeking help and support is critical.

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Sara Egnatz BSN, RN-BC

Sara Egnatz, BSN, RN-BC, is a seasoned registered nurse with 30 years of experience and is currently practicing at a large hospital in

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We review published medical research in respected scientific journals to arrive at our conclusions about a product or health topic. This ensures the highest standard of scientific accuracy.

[1] Chang SM, Chen CH. Effects of an intervention with drinking chamomile tea on sleep quality and depression in sleep disturbed postnatal women: a randomized controlled trial. J Adv Nurs. 2016;72(2):306–15. doi: 10.1111/jan.12836.
[2] Plieger T, Melchers M, Montag C, Meermann R, Reuter M. Life stress as potential risk factor for depression and burnout. Burnout Res. 2015;2:19–24.
[3] Appleton KM, Sallis HM, Perry R, et al. Omega-3 fatty acids for depression in adults. Cochrane Database of Systematic Reviews. 2015;(11):CD004692.
[4] Badawy AA, Morgan CJ, Lovett JW, et al. Decrease in circulating tryptophan availability to the brain after acute ethanol consumption by normal volunteers: Implications for alcohol-induced aggressive behaviour and depression. Pharmacopsychiatry. 1995;28:93–7.
[5] Chouet J, Ferland G, Féart C, Rolland Y, Presse N, Boucher K, et al.. Dietary vitamin K intake is associated with cognition and behaviour among geriatric patients: the CLIP study. Nutrients. (2015) 7:6739–50. 10.3390/nu7085306
[6] Kessler RC, Soukup J, Davis RB, Foster DF, Wilkey SA, Van Rompay MI, Eisenberg DM. The use of complementary and alternative therapies to treat anxiety and depression in the united states. Am J Psychiatry. 2001;158:289–94.
[7] Putman MS, Pitts SA, Milliren CE, Feldman HA, Reinold K, Gordon CM. A randomized clinical trial of vitamin D supplementation in healthy adolescents. J Adolesc Health. 2013 May;52(5):592-8. doi: 10.1016/j.jadohealth.2012.10.270. Epub 2012 Dec 23. PMID: 23608721; PMCID: PMC3634127.
[8] Linde K, Berner MM, Kriston L. St. John’s wort for major depression. Cochrane Database of Systematic Reviews. 2009;(4):CD000448.

**This is a subjective assessment based on the strength of the available informations and our estimation of efficacy.

*Result may vary. If you are pregnant, nursing, have a serious medical condition, or have a history of heart conditions we suggest consulting with a physician before using any supplement. The information contained in this website is provided for general informational purposes only. It is not intended to diagnose, treat, cure, or prevent any disease and should not be relied upon as a medical advice. Always consult your doctor before using any supplements.

Disclosure of Material connection: Some of the links in the post above are "associate sales links." This means if you can click on the link and purchase an item, we will receive a commission. Regardless, we only recommend products or services which we use personally and/or believe will add value to our readers. We are disclosing this in accordance with the Federal Trade Commission's 16 CFR, Part 255: "Guides Concerning the Use of Endorsements and Testimonials."